Matisse Vincent Thybulle (born March 4, 1997) is an Australian-American professional basketball player for the Portland Trail Blazers of the National Basketball Association (NBA). He was selected in the first round of the 2019 NBA draft with the 20th overall pick. He was named to the NBA All-Defensive Second Team in 2021 and 2022.

Thybulle played college basketball for the Washington Huskies. As a senior in 2019, he was recognized as the top defender in the nation with the Naismith Defensive Player of the Year and the Lefty Driesell Award. Thybulle also earned first-team all-conference honors in the Pac-12, and repeated as the Pac-12 Defensive Player of the Year.

Thybulle is a dual American-Australian citizen and spent around seven years of his childhood in Sydney. He was a member of the Australian national team at the 2020 Summer Olympics in Tokyo.